A General Method for the Divergent Synthesis of C‐9 Functionalised Sialic Acid Derivatives,European Journal of Organic Chemistry

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A General Method for the Divergent Synthesis of C‐9 Functionalised Sialic Acid Derivatives
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2020-09-08 , DOI: 10.1002/ejoc.202001049
Abdullah A Hassan ₁ , Stefan Oscarson ₂

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A general and operationally simple protocol for the synthesis of C‐9 functionalised neuraminic acid derivatives from N‐acetylneuraminic acid is described. During the synthetic endeavor, an efficient way to introduce sialic acid “unfriendly” benzyl groups was established. Additionally, a working methodology towards unnatural β‐configured neuraminic acid glycosides is reported.