Synthesis of 3‐Unsubstituted Phthalides from Aryl Amides and Paraformaldehyde via Ruthenium(II)‐Catalyzed C–H Activation,European Journal of Organic Chemistry

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Synthesis of 3‐Unsubstituted Phthalides from Aryl Amides and Paraformaldehyde via Ruthenium(II)‐Catalyzed C–H Activation
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2020-09-07 , DOI: 10.1002/ejoc.202001160
Chao Zhou ₁ , Junqi Zhao ₂ , Wenkun Chen ₁ , Mukhtar Imerhasan ₂ , Jun Wang ₁

Affiliation

A straightforward and convenient route has been developed for the synthesis of 3‐unsubstituted phthalide derivatives from aryl amides and paraformaldehyde by ruthenium(II)‐catalyzed C–H activation. The reaction proceeds through tandem ortho‐hydroxymethylation of aryl amide and subsequent intramolecular lactonization.