PER2 C111G polymorphism, cognitive reserve and cognition in subjective cognitive decline and mild cognitive impairment. A 10-year follow-up study.,European Journal of Neurology

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PER2 C111G polymorphism, cognitive reserve and cognition in subjective cognitive decline and mild cognitive impairment. A 10-year follow-up study.
European Journal of Neurology ( IF 4.5 ) Pub Date : 2020-09-08 , DOI: 10.1111/ene.14518
V Bessi ₁ , G Giacomucci ₁ , S Mazzeo ₁ , S Bagnoli ₁ , S Padiglioni ₁ , J Balestrini ₁ , G Tomaiuolo ₂ , I Piaceri ₁ , M Carraro ₁ , L Bracco ₁ , S Sorbi _{1,

3} , B Nacmias _{1,

3}

Affiliation

CLOCK and PER2 genes have been implicated in sleep–wake cycle alterations and neurodegenerative diseases. Our aim was to evaluate the effect of CLOCK T3111C and PER2 C111G on cognitive functioning in subjective cognitive decline (SCD) patients and mild cognitive impairment (MCI) patients at the baseline of a longitudinal study, and the effect of these two polymorphisms on the progression to Alzheimer’s disease (AD) of the two groups.

中文翻译：

PER2 C111G 多态性、认知储备和认知在主观认知衰退和轻度认知障碍中的作用。一项为期 10 年的随访研究。

CLOCK和PER2基因与睡眠-觉醒周期改变和神经退行性疾病有关。我们的目的是在纵向研究的基线评估CLOCK T3111C 和PER2 C111G 对主观认知衰退 (SCD) 患者和轻度认知障碍 (MCI) 患者认知功能的影响，以及这两种多态性对进展的影响对两组的阿尔茨海默病（AD）。

更新日期：2020-09-08

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