A study was conducted to characterize the effects of dietary oxidized fish oil on the growth performance, immunity and antioxidant status of genetically improved farmed tilapia (Oreochromis niloticus) and to determine the role of ferulic acid on the oxidative damage induced by the oxidized fish oil. The tilapia (13.73 ± 0.31 g) were fed four experimental diets containing untreated (peroxide value, POV: 2.2 meq/kg) and highly oxidized (POV: 120.6 meq/kg) fish oil either with or without ferulic acid (0 or 400 mg/kg) supplementation for 12 weeks. From the results, the oxidized fish oil treatments increased antioxidant enzyme activities and MDA values but decreased the weight gain and the immunological parameters in tilapia. Meanwhile, the serum biochemical indices were significantly affected by the oxidized fish oil. Besides, the addition of ferulic acid partially counteracted the free radical‐induced damage and improved the health status of tilapia. In conclusion, the oxidized fish oil may induce oxidative stress, destroy liver, dysregulate lipid metabolism as well as reduce non‐specific immunity, and eventually result in growth inhibition of tilapia. The ferulic acid supplementation partially offset the negative effects of the oxidized fish oil on tilapia.

中文翻译：

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阿魏酸对饲喂氧化鱼油的转基因罗非鱼（Oreochromis niloticus）生长性能，免疫力和抗氧化状态的影响

进行了一项研究，以表征膳食氧化鱼油对转基因养殖罗非鱼（Oreochromis niloticus）的生长性能，免疫力和抗氧化状态的影响），并确定阿魏酸对氧化鱼油引起的氧化损伤的作用。给罗非鱼（13.73±0.31 g）喂食四种实验饮食，这些饮食含有未经处理的（过氧化物值，POV：2.2 meq / kg）和高度氧化的（POV：120.6 meq / kg）鱼油，有或没有阿魏酸（0或400 mg / kg）补充，持续12周。从结果来看，氧化鱼油处理增加了罗非鱼的抗氧化酶活性和MDA值，但降低了体重增加和免疫学参数。同时，氧化鱼油显着影响血清生化指标。此外，添加阿魏酸可部分抵消自由基引起的损害并改善罗非鱼的健康状况。总之，氧化的鱼油可能会引起氧化应激，破坏肝脏，脂质代谢失调以及降低非特异性免疫，最终导致罗非鱼的生长受到抑制。阿魏酸的补充部分抵消了氧化鱼油对罗非鱼的负面影响。