Although the function of the circulating immune cell compartment has been studied in detail for decades, limitations in terms of access and cell yields from peripheral tissues have restricted our understanding of tissue-based immunity, particularly in humans. Recent advances in high-throughput protein analyses, transcriptional profiling, and epigenetics have partially overcome these obstacles. Innate lymphoid cells (ILCs) are predominantly tissue-resident, and accumulating data indicate that they have significant tissue-specific functions. We summarize current knowledge of ILC phenotypes in various tissues in mice and humans, aiming to clarify ILC immunity in distinct anatomical locations.

尽管已对循环免疫细胞区室的功能进行了数十年的详细研究，但在进入途径和来自周围组织的细胞产量方面的局限性限制了我们对基于组织的免疫的理解，特别是在人类中。高通量蛋白质分析，转录概况分析和表观遗传学的最新进展已部分克服了这些障碍。先天性淋巴样细胞（ILC）主要位于组织中，并且积累的数据表明它们具有重要的组织特异性功能。我们总结了小鼠和人类各种组织中ILC表型的当前知识，旨在阐明不同解剖位置的ILC免疫力。