Over 85% of all genomic DNA in eukaryotes is organized in arrays of nucleosomes, the basic organizational principle of chromatin. The tight interaction of DNA with histones represents a significant barrier for all DNA-dependent machineries. This is in part overcome by enzymes, termed ATP-dependent remodelers, that are recruited to nucleosomes at defined locations and modulate their structure. There are several different classes of remodelers, and all use specific nucleosome features to bind to and alter nucleosomes. This review highlights and summarizes areas of interactions with the nucleosome that allow remodeling to occur.

中文翻译：

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核小体遇到他们的重塑剂比赛。

真核生物中超过85％的所有基因组DNA都是以核小体（染色质的基本组织原理）阵列组织的。DNA与组蛋白的紧密相互作用代表了所有依赖DNA的机器的重要障碍。这可以通过被称为ATP依赖重塑剂的酶部分克服，该酶在限定的位置募集到核小体并调节其结构。有几种不同类别的重塑剂，并且都使用特定的核小体特征来结合和改变核小体。这篇综述突出并总结了与核小体相互作用的区域，这些区域允许重塑发生。