TopBP1/Rad4/Dpb11 is an essential eukaryotic protein with important roles in DNA replication, DNA repair, DNA damage checkpoint activation, and chromosome segregation. TopBP1 serves as a scaffold to assemble protein complexes in a phosphorylation-dependent manner via its multiple BRCT-repeats. Recently, it has become clear that TopBP1 is repurposed to scaffold different processes dependent on cell cycle regulated changes in phosphorylation of client proteins. Here we review the functions of human TopBP1 in maintaining genome integrity during mitosis.

中文翻译：

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TopBP1在有丝分裂过程中保持基因组完整性的功能

TopBP1/Rad4/Dpb11 是一种必需的真核蛋白，在 DNA 复制、DNA 修复、DNA 损伤检查点激活和染色体分离中具有重要作用。TopBP1 作为支架，通过其多个 BRCT 重复以磷酸化依赖性方式组装蛋白质复合物。最近，很明显，TopBP1 被重新用于支架依赖于细胞周期调节的客户蛋白磷酸化变化的不同过程。在这里，我们回顾了人类 TopBP1 在有丝分裂过程中维持基因组完整性的功能。