Abstract Reducing the corrosion rate and improving the biocompatibility are the main challenges that impede the successful application of magnesium (Mg) and its alloy in clinical applications. Herein, we report a type of composite coating based on biocompatible dextran-caffeic acid (dextran-CA) and electroactive tetraaniline (TANi) for simultaneous improvement of cytocompatibility and corrosion resistance of Mg alloy. Specifically, dextran-CA was synthesized and co-assembled with TANi into composite nanoparticles, which were coated on AZ31 Mg alloy by electrophoretic deposition (EPD) and crosslinked under UV irradiation. Electrochemical analysis and in vitro degradation tests demonstrated that the corrosion rate of dextran-CA/TANi-coated Mg alloy significantly decreased owing to the dense coating as well as the addition of TANi. The composite coating also improved the cytocompatibility of Mg alloy as confirmed by in vitro cytotoxicity assays and cell adhesion tests. Results indicate that dextran-CA/TANi composite coatings can provide new opportunities for the clinical application of Mg alloy.

中文翻译：

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葡聚糖-咖啡酸/四苯胺复合涂层同时提高镁合金的细胞相容性和耐腐蚀性

摘要 降低腐蚀速率和提高生物相容性是阻碍镁（Mg）及其合金在临床应用中成功应用的主要挑战。在此，我们报告了一种基于生物相容性葡聚糖-咖啡酸 (dextran-CA) 和电活性四苯胺 (TANi) 的复合涂层，用于同时提高镁合金的细胞相容性和耐腐蚀性。具体而言，葡聚糖-CA被合成并与TANi共组装成复合纳米颗粒，通过电泳沉积（EPD）涂覆在AZ31镁合金上并在UV照射下交联。电化学分析和体外降解试验表明，由于涂层致密以及 TANi 的加入，葡聚糖-CA/TANi 包覆镁合金的腐蚀速率显着降低。体外细胞毒性试验和细胞粘附试验证实，复合涂层还提高了镁合金的细胞相容性。结果表明葡聚糖-CA/TANi复合涂层可为镁合金的临床应用提供新的机遇。