Abstract Enabling angiogenesis is critical for the success of tissue repair therapies and the fate of tissue-engineered constructs. Although many biochemical signaling molecules have been used, their biological functions in vivo are known to be limited, mainly due to their short lifetime and poor activity. Matrices (or engineered biomaterials), beyond the biochemical signals, play pivotal roles in stimulating angiogenic processes. Here we discuss the proangiogenic effort taken to repair and regenerate various tissues including skin, bone, muscle and nerve, focusing on the roles of engineered matrices. This includes the design of pore structure and physico-chemical properties (nanotopology, stiffness, chemistry and degradability), the tailoring of matrices for proper presentation of growth factors and their crosstalks with adhesion ligands, the controlled and sustained delivery of angiogenic molecules and metallic ions, and the engineering of cells and construction of prevascularized tissues. Collectively, the materials-driven strategies are envisaged to tune the cell and tissue microenvironments where angiogenic events can be significantly favored through the matrix cues and properly presented or delivered signaling molecules and cells.

中文翻译：

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材料在组织再生中促进血管生成的作用

摘要 启用血管生成对于组织修复疗法的成功和组织工程构建体的命运至关重要。尽管已经使用了许多生化信号分子，但已知它们在体内的生物学功能是有限的，主要是由于它们的寿命短和活性差。除了生化信号外，基质（或工程生物材料）在刺激血管生成过程中发挥着关键作用。在这里，我们讨论了修复和再生各种组织（包括皮肤、骨骼、肌肉和神经）所采取的促血管生成努力，重点是工程基质的作用。这包括孔结构和物理化学性质（纳米拓扑学、刚度、化学和降解性）的设计、矩阵的定制以正确呈现生长因子及其与粘附配体的串扰，血管生成分子和金属离子的受控和持续递送，以及细胞工程和预血管化组织的构建。总的来说，材料驱动的策略被设想来调整细胞和组织微环境，其中血管生成事件可以通过基质线索显着有利，并正确呈现或传递信号分子和细胞。