Glucocorticoid drugs are commonly used in the treatment of several conditions, including autoimmune diseases, asthma and cancer. Despite their widespread use and knowledge of biological pathways via which they act, much remains to be learned about the cell type-specific mechanisms of glucocorticoid action and the reasons why patients respond differently to them. In recent years, human and in vitro studies have addressed these questions with genomics, transcriptomics and other omics approaches. Here, we summarize key insights derived from omics studies of glucocorticoid response, and we identify existing knowledge gaps related to mechanisms of glucocorticoid action that future studies can address.

糖皮质激素药物常用于治疗多种疾病，包括自身免疫性疾病、哮喘和癌症。尽管它们的广泛使用和对它们作用的生物学途径的了解，但关于糖皮质激素作用的细胞类型特异性机制以及患者对它们反应不同的原因仍有许多需要了解。近年来，人类和体外研究通过基因组学、转录组学和其他组学方法解决了这些问题。在这里，我们总结了从糖皮质激素反应的组学研究中得出的关键见解，并确定了与糖皮质激素作用机制相关的现有知识空白，未来的研究可以解决这些空白。