We aimed to detail language profiles, brain metabolic patterns and proportion of Alzheimer's disease biomarkers in a cohort of patients with mixed primary progressive aphasia (mPPA). We considered 58 patients with PPA: 10 with non-fluent/agrammatic variant (nfvPPA), 16 with semantic variant (svPPA), 21 with logopenic variant (lvPPA) and 9 with mPPA. Patients with mPPA were further classified as 4 nf/lvPPA (with prevailing features for nfvPPA and lvPPA) and 5 s/lvPPA (with prevailing features for svPPA and lvPPA). Nf/lvPPA patients were characterized by higher proportion of Naming impairment compared to nfvPPA and more frequent Grammatical Errors and Phonologic Errors than lvPPA. S/lvPPA had higher proportion of impairment in Sentences Repetition compared to svPPA and in Single-word Comprehension compared to lvPPA. 100% of nf/lvPPA and 40% of s/lvPPA had Aβ positive biomarkers. Brain hypometabolic pattern in Nf/lvPPA was consistent with lvPPA, while s/lvPPA had a brain metabolism resembling svPPA. We concluded that nf/lvPPA patients might be considered as PPA variant due to Alzheimer's disease and s/lvPPA group mainly included patients with svPPA.

中文翻译：

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混合原发性进行性失语症患者的语言特征、脑代谢模式和淀粉样蛋白 β 生物标志物阳性率。

我们旨在详细描述混合原发性进行性失语 (mPPA) 患者队列中的语言特征、大脑代谢模式和阿尔茨海默病生物标志物的比例。我们考虑了 58 名 PPA 患者：10 名具有非流利/语法变体 (nfvPPA)，16 名具有语义变体 (svPPA)，21 名具有 logopenic 变体 (lvPPA) 和 9 名具有 mPPA。mPPA 患者进一步分为 4 nf/lvPPA（具有 nfvPPA 和 lvPPA 的主要特征）和 5 s/lvPPA（具有 svPPA 和 lvPPA 的主要特征）。与 nfvPPA 相比，Nf/lvPPA 患者的命名障碍比例更高，语法错误和语音错误比 lvPPA 更频繁。与 svPPA 相比，S/lvPPA 在句子重复和单字理解方面的损伤比例高于 lvPPA。100% 的 nf/lvPPA 和 40% 的 s/lvPPA 具有 Aβ 阳性生物标志物。Nf/lvPPA 的脑代谢减退模式与 lvPPA 一致，而 s/lvPPA 的脑代谢类似于 svPPA。我们得出结论，由于阿尔茨海默病，nf/lvPPA 患者可能被认为是 PPA 变体，s/lvPPA 组主要包括 svPPA 患者。