At present, glyphosate (GLP) is the most produced and used herbicide in the world. With the large-scale use of glyphosate-based herbicides (GBHs), their toxic effects on animals and plants have increasingly become a concern. Based on the Codex Alimentarius Commission (CODEX) dose (20 mg kg^-1) and the dose set by the government (40 mg kg^-1), four experimental groups in which Roundup® (R) herbicide was added to the feed of weaned piglets at GLP concentrations of 0, 10, 20, and 40 mg kg^-1 were designed. The results showed that R had no significant effect on the vulvar size or index of reproductive organs but that it could affect the tissue morphology and ultrastructure of the uterus and ovary. With the increase in GLP concentration, the activities of antioxidant enzymes [SOD (P<0.05) and GPx (P=0.002)] in the uterus showed significant increases. Compared with the control group, the content of hydrogen peroxide (H₂O₂) in the treatment groups increased significantly (P<0.05), the malondialdehyde (MDA) content in the 10 mg kg^-1 treatment group was significantly higher than that in the control group. We measured hypothalamic-pituitary-ovarian axis (HPOA) hormones and also found that GLP significantly increased luteinizing hormone-releasing hormone (LHRH), gonadotropin-releasing hormone (GnRH) and testosterone (T) content (P<0.05) and decreased follicle-stimulating hormone (FSH) content (P<0.05). In summary, although R does not affect the vulvar size or reproductive organ index of weaned piglets, it changes the morphology and ultrastructure of the uterus and ovaries, interferes with the synthesis and secretion of HPOA hormones, and causes changes in the balance of the antioxidant system of uterus. This study provided a theoretical basis for preventing reproductive system harm caused by GBHs.

目前，草甘膦（GLP）是世界上生产和使用最多的除草剂。随着草甘膦除草剂（GBHs）的大规模使用，其对动植物的毒性作用日益引起人们的关注。根据食品法典委员会（CODEX）剂量（20 mg kg ^-1 ）和政府设定剂量（40 mg kg ^-1 ），在断奶仔猪饲料中添加农达®（R）除草剂的四个实验组设计了GLP浓度为0、10、20和40 mg kg ^-1的仔猪。结果表明，R对外阴大小或生殖器官指数无显着影响，但可影响子宫和卵巢的组织形态和超微结构。随着GLP浓度的增加，子宫内抗氧化酶[SOD( P <0id=175>P=0.002)]活性显着增加。与对照组相比，治疗组过氧化氢（H ₂ O ₂ ）含量显着升高（ P <0 id=179>-1 治疗组显着高于对照组。我们测量了下丘脑-垂体- 卵巢轴 (HPOA) 激素，还发现 GLP 显着增加促黄体激素释放激素 (LHRH)、促性腺激素释放激素 (GnRH) 和睾酮 (T) 含量 ( P <0 id=181>P <0.05)。综上所述，R虽然不影响断奶仔猪的外阴大小或生殖器官指数，但会改变子宫和卵巢的形态和超微结构，干扰HPOA激素的合成和分泌，引起抗氧化系统平衡的改变子宫。 该研究为预防GBHs对生殖系统造成的危害提供了理论依据。