Severe respiratory infections were highlighted in the SARS-CoV outbreak in 2002, as well as MERS-CoV, in 2012. Recently, the novel CoV (COVID-19) has led to severe respiratory damage to humans and deaths in Asia, Europe, and Americas, which allowed the WHO to declare the pandemic state. Notwithstanding all impacts caused by Coronaviruses, it is evident that the development of new antiviral agents is an unmet need. In this review, we provide a complete compilation of all potential antiviral agents targeting macromolecular structures from these Coronaviruses (Coronaviridae), providing a medicinal chemistry viewpoint that could be useful for designing new therapeutic agents.

严重的呼吸道感染在2002年的SARS-CoV爆发以及2012年的MERS-CoV中得到了强调。最近，新型CoV（COVID-19）导致严重的呼吸道伤害，并在亚洲，欧洲和欧洲造成死亡。美洲，这允许世界卫生组织宣布大流行状态。尽管冠状病毒引起了所有影响，但很明显，新抗病毒药物的开发仍未得到满足。在这篇综述中，我们提供了针对这些冠状病毒（Coronaviridae）中针对大分子结构的所有潜在抗病毒药的完整汇编，提供了可用于设计新治疗剂的药物化学观点。