Severe respiratory infections were highlighted in the SARS-CoV outbreak in 2002, as well as MERS-CoV, in 2012. Recently, the novel CoV (COVID-19) has led to severe respiratory damage to humans and deaths in Asia, Europe, and Americas, which allowed the WHO to declare the pandemic state. Notwithstanding all impacts caused by Coronaviruses, it is evident that the development of new antiviral agents is an unmet need. In this review, we provide a complete compilation of all potential antiviral agents targeting macromolecular structures from these Coronaviruses (Coronaviridae), providing a medicinal chemistry viewpoint that could be useful for designing new therapeutic agents.

2002 年的 SARS-CoV 爆发以及 2012 年的 MERS-CoV 爆发突出了严重呼吸道感染。最近，新型冠状病毒 (COVID-19) 在亚洲、欧洲和中东地区导致人类严重呼吸道损伤和死亡。美洲，允许世界卫生组织宣布大流行状态。尽管冠状病毒造成了种种影响，但显然，新型抗病毒药物的开发仍是一个未得到满足的需求。在这篇综述中，我们提供了针对这些冠状病毒（冠状病毒科）大分子结构的所有潜在抗病毒药物的完整汇编，提供了可用于设计新治疗药物的药物化学观点。