Obesity is an alarming threat to health in Egypt. More than one in three Egyptians is obese, the highest rate in the world. We aimed to delineate the variability of inflammation and endothelial dysfunction markers among Egyptian females with different obesity classes. Out of 130 females, 70 were categorized into 3 obesity groups: Class I, BMI 30-34.9kg/m2; Class II, BMI 35-39.9 kg/m2 and Class III BMI ≥ 40kg/ m2, besides 60 control subjects. Anthropometric measurements were recorded and serum levels of tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), interleukin 6 (IL-6), IL-12, soluble intercellular adhesion molecule 1 (sICAM-1) and soluble vascular adhesion molecule 1(sVCAM-1) were assessed among participants. In all three classes of obesity, significant increase (P <0.05) in BMI, waist-hip ratio, fat mass and body fat mass % were noted. CRP and sVCAM-1 levels were increased among the 3 obesity groups. TNF-α levels were increased in class II and III obesity groups. IL-6 and IL-12 levels were elevated in class I and class III groups. While, ICAM-1 levels were increased in class III obesity group. Based on individuals' BMI, serum levels of TNF-α, CRP, IL-6, IL-12, sVCAM-1 and sICAM-1 are differentially altered with the progression of obesity. We strongly support the hypothesis that, as the obesity rate is still mounting, a subclinical inflammatory reaction has a role in pathogenesis of obesity and emphasize the elevation of endothelial dysfunction in individuals with obesity.

中文翻译：

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埃及I-III级肥胖女性的炎症和内皮功能障碍指数。

肥胖是对埃及健康的令人震惊的威胁。三分之一以上的埃及人肥胖，是世界上肥胖率最高的国家。我们的目的是在具有不同肥胖类别的埃及女性中描述炎症和内皮功能障碍标志物的变异性。在130位女性中，有70位被归类为3个肥胖组：I级，BMI 30-34.9kg / m2； BMI 30-34.9kg / m2。II类，BMI 35-39.9 kg / m2和III类BMI≥40kg / m2，此外还有60名对照受试者。记录人体测量数据，并检测血清肿瘤坏死因子-α（TNF-α），C反应蛋白（CRP），白介素6（IL-6），IL-12，可溶性细胞间粘附分子1（sICAM-1）和在参与者中评估了可溶性血管粘附分子1（sVCAM-1）。在这三类肥胖中，BMI，腰臀比，记录脂肪质量和体脂肪质量％。在3个肥胖组中，CRP和sVCAM-1水平升高。II类和III类肥胖组的TNF-α水平升高。I级和III级组的IL-6和IL-12水平升高。同时，III类肥胖组的ICAM-1水平升高。根据个体的BMI，随着肥胖的发展，血清TNF-α，CRP，IL-6，IL-12，sVCAM-1和sICAM-1的水平会有差异。我们坚决支持以下假设：由于肥胖率仍在上升，亚临床炎症反应在肥胖的发病机理中具有重要作用，并强调了肥胖个体中内皮功能障碍的加剧。I级和III级组的IL-6和IL-12水平升高。同时，III类肥胖组的ICAM-1水平升高。根据个体的BMI，随着肥胖的发展，血清TNF-α，CRP，IL-6，IL-12，sVCAM-1和sICAM-1的水平会有差异。我们坚决支持以下假设：由于肥胖率仍在上升，亚临床炎症反应在肥胖的发病机理中起着重要作用，并强调了肥胖个体中内皮功能障碍的加剧。I级和III级组的IL-6和IL-12水平升高。同时，III类肥胖组的ICAM-1水平升高。根据个体的BMI，随着肥胖的发展，血清TNF-α，CRP，IL-6，IL-12，sVCAM-1和sICAM-1的水平会有差异。我们坚决支持以下假设：由于肥胖率仍在上升，亚临床炎症反应在肥胖的发病机理中起着重要作用，并强调了肥胖个体中内皮功能障碍的加剧。