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Rapid construction of cyclopenta[b]naphthalene frameworks from propargylic alcohol tethered methylenecyclopropanes.
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2020-09-07 , DOI: 10.1039/d0ob01732a
Hao-Zhao Wei 1 , Quan-Zhe Li 1 , Yin Wei 2 , Min Shi 3
Affiliation  

We have developed a new synthetic methodology for the rapid construction of cyclopenta[b]naphthalene frameworks from the reaction of propargylic alcohol tethered methylenecyclopropanes with mesyl chloride in the presence of triethylamine through cascade cyclization. The reaction can be performed under mild conditions without the use of transition metals, affording the target products in moderate to good yields, and this cyclization reaction process can be scaled up to a gram-scale synthesis.

中文翻译:

由炔丙醇系链的亚甲基环丙烷快速构建环戊[b]萘骨架。

我们已经开发了一种新的合成方法,可以通过在三乙胺存在下通过级联环化反应,将炔丙醇系链的亚甲基环丙烷与甲磺酰氯反应,快速构建环戊[ b ]萘骨架。该反应可以在温和的条件下进行而无需使用过渡金属,以中等至良好的收率提供目标产物,并且该环化反应过程可以按比例放大至克级合成。
更新日期:2020-09-30
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