A glycidyl methacrylate modified collagen/polyethylene glycol diacrylate hydrogel: a mechanically strong hydrogel for loading levofloxacin,New Journal of Chemistry

当前位置： X-MOL 学术 › New J. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

A glycidyl methacrylate modified collagen/polyethylene glycol diacrylate hydrogel: a mechanically strong hydrogel for loading levofloxacin
New Journal of Chemistry ( IF 2.7 ) Pub Date : 2020-09-07 , DOI: 10.1039/d0nj02853c
Weilin Li _{1,

2,

3,

4,

5} , Xialian Fan _{1,

2,

3,

4,

6} , Ying Wang _{1,

2,

3,

4} , Jingru Wang _{1,

2,

3,

4} , Mengya Li _{1,

2,

3,

4} , Xiumin Li _{1,

2,

3,

4} , Keyong Tang _{1,

2,

3,

4} , Guangming Wan _{4,

6,

7}

Affiliation

Artificial suturing of incision after ocular trauma is very complicated and is prone to infection. A material with suitable mechanical strength and good biocompatibility can be expected to solve this problem. In this work, a levofloxacin-loaded collagen/polyethylene glycol diacrylate hydrogel modified with glycidyl methacrylate was synthesized through in situ UV irradiation polymerization. This hydrogel showed a three-dimensional porous structure and good compressive strength of 3.19 MPa, as well as high hydrophilicity, the desired degradation period and good biocompatibility, indicating potential for application in ocular surgical incisions. In addition, the levofloxacin-loaded hydrogel is endowed with good antibacterial activity for Escherichia coli, and good sustained releasing effect of levofloxacin. A suitable environment is provided for preventing infections, which might promote the treatment of ocular incision.

中文翻译：

甲基丙烯酸缩水甘油酯改性的胶原蛋白/聚乙二醇二丙烯酸酯水凝胶：一种机械强度高的水凝胶，可负载左氧氟沙星

眼外伤后的人工缝合切口非常复杂，容易感染。具有合适的机械强度和良好的生物相容性的材料有望解决该问题。在这项工作中，通过原位紫外辐射聚合合成了负载左氧氟沙星的胶原蛋白/甲基丙烯酸缩水甘油酯改性的聚乙二醇二丙烯酸酯水凝胶。该水凝胶显示出三维多孔结构和3.19 MPa的良好抗压强度，以及高亲水性，所需的降解时间和良好的生物相容性，表明其可用于眼外科切口。此外，负载左氧氟沙星的水凝胶对大肠杆菌具有良好的抗菌活性，左氧氟沙星具有良好的持续释放作用。提供了合适的环境以防止感染，这可能会促进眼切口的治疗。

更新日期：2020-10-15

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11