Sex-related differences in the occurrence of autoimmune diseases is well documented, with females showing a greater propensity to develop these diseases than their male counterparts. Sex hormones, namely dihydrotestosterone and estrogens, have been shown to ameliorate the severity of inflammatory diseases. Immunologically, the beneficial effects of sex hormones have been ascribed to the suppression of effector lymphocyte responses accompanied by immune deviation from pro-inflammatory to anti-inflammatory cytokine production. In this review, we present our view of the mechanisms of sex hormones that contribute to their ability to suppress autoimmune responses with an emphasis on the pathogenesis of experimental autoimmune encephalomyelitis.

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性激素在自身免疫中的机制：关注 EAE。

自身免疫性疾病的发生与性别相关的差异已有充分记录，女性比男性更容易患这些疾病。性激素，即二氢睾酮和雌激素，已被证明可以减轻炎症性疾病的严重程度。从免疫学角度来看，性激素的有益作用归因于效应淋巴细胞反应的抑制，并伴随着免疫从促炎细胞因子的产生转向抗炎细胞因子的产生。在这篇综述中，我们提出了对性激素机制的看法，性激素有助于抑制自身免疫反应，重点是实验性自身免疫性脑脊髓炎的发病机制。