Rh(III)-Catalyzed Dual C-H Functionalization/Cyclization Cascade by a Removable Directing Group: A Method for Synthesis of Polycyclic Fused Pyrano[de]Isochromenes.,The Journal of Organic Chemistry

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Rh(III)-Catalyzed Dual C-H Functionalization/Cyclization Cascade by a Removable Directing Group: A Method for Synthesis of Polycyclic Fused Pyrano[de]Isochromenes.
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2020-09-07 , DOI: 10.1021/acs.joc.0c01228
Zhihao Shu _{1,

2} , Jianhui Zhou ₂ , Junyou Li _{2,

3} , Yilang Cheng _{2,

3} , Hong Liu _{1,

2} , Dechuan Wang ₁ , Yu Zhou _{2,

3}

Affiliation

An interesting Rh(III)-catalyzed dual C–H functionalization/cyclization cascade of azomethine imine with diazophosphonate by a removable directing group for the synthesis of highly fused pyrano[de]isochromene has been achieved. The transformation shows that the desired pyrano[de]isochromenes with two oxygen atoms on its core scaffold could be constructed with good to excellent yields (up to 86%) via a facile one-pot, multiple-step cascade reaction, along with broad generality and versatility.

中文翻译：

可移动的导向基团对Rh（III）催化的双CH官能化/环化级联反应：一种多环稠合吡喃并[异]异苯二酮的合成方法。

通过可移动的导向基团，用于合成高度稠合的吡喃并[ de ]异戊二烯的Rh（III）催化的偶氮甲亚胺与重氮膦酸酯的双重CH-H官能化/环化级联反应已经实现。该转化表明，通过简便的一锅多步级联反应以及广泛的通用性，可以构筑所需的在其核心骨架上带有两个氧原子的吡喃并[ de ]异色酮，收率良好至优异（高达86％）和多功能性。

更新日期：2020-10-02

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