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Rh(III)-Catalyzed Dual C-H Functionalization/Cyclization Cascade by a Removable Directing Group: A Method for Synthesis of Polycyclic Fused Pyrano[de]Isochromenes.
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2020-09-07 , DOI: 10.1021/acs.joc.0c01228
Zhihao Shu 1, 2 , Jianhui Zhou 2 , Junyou Li 2, 3 , Yilang Cheng 2, 3 , Hong Liu 1, 2 , Dechuan Wang 1 , Yu Zhou 2, 3
Affiliation  

An interesting Rh(III)-catalyzed dual C–H functionalization/cyclization cascade of azomethine imine with diazophosphonate by a removable directing group for the synthesis of highly fused pyrano[de]isochromene has been achieved. The transformation shows that the desired pyrano[de]isochromenes with two oxygen atoms on its core scaffold could be constructed with good to excellent yields (up to 86%) via a facile one-pot, multiple-step cascade reaction, along with broad generality and versatility.

中文翻译:

可移动的导向基团对Rh(III)催化的双CH官能化/环化级联反应:一种多环稠合吡喃并[异]异苯二酮的合成方法。

通过可移动的导向基团,用于合成高度稠合的吡喃并[ de ]异戊二烯的Rh(III)催化的偶氮甲亚胺与重氮膦酸酯的双重CH-H官能化/环化级联反应已经实现。该转化表明,通过简便的一锅多步级联反应以及广泛的通用性,可以构筑所需的在其核心骨架上带有两个氧原子的吡喃并[ de ]异色酮,收率良好至优异(高达86%)和多功能性。
更新日期:2020-10-02
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