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A Robust and Biocompatible Bismuth Ellagate MOF Synthesized Under Green Ambient Conditions
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2020-09-07 , DOI: 10.1021/jacs.0c07525
Erik Svensson Grape 1 , J Gabriel Flores 2, 3 , Tania Hidalgo 4 , Eva Martínez-Ahumada 2 , Aída Gutiérrez-Alejandre 5 , Audrey Hautier 6 , Daryl R Williams 7 , Michael O'Keeffe 8 , Lars Öhrström 9 , Tom Willhammar 1 , Patricia Horcajada 4 , Ilich A Ibarra 2 , A Ken Inge 1
Affiliation  

The first bioinspired microporous metal–organic framework (MOF) synthesized using ellagic acid, a common natural antioxidant and polyphenol building unit, is presented. Bi2O(H2O)2(C14H2O8)·nH2O (SU-101) was inspired by bismuth phenolate metallodrugs, and could be synthesized entirely from nonhazardous or edible reagents under ambient aqueous conditions, enabling simple scale-up. Reagent-grade and affordable dietary supplement-grade ellagic acid was sourced from tree bark and pomegranate hulls, respectively. Biocompatibility and colloidal stability were confirmed by in vitro assays. The material exhibits remarkable chemical stability for a bioinspired MOF (pH = 2–14, hydrothermal conditions, heated organic solvents, biological media, SO2 and H2S), attributed to the strongly chelating phenolates. A total H2S uptake of 15.95 mmol g–1 was recorded, representing one of the highest H2S capacities for a MOF, where polysulfides are formed inside the pores of the material. Phenolic phytochemicals remain largely unexplored as linkers for MOF synthesis, opening new avenues to design stable, eco-friendly, scalable, and low-cost MOFs for diverse applications, including drug delivery.

中文翻译:

在绿色环境条件下合成的坚固且生物相容的鞣花酸铋 MOF

提出了第一个使用鞣花酸(一种常见的天然抗氧化剂和多酚结构单元)合成的仿生微孔金属有机框架(MOF)。Bi2O(H2O)2(C14H2O8)·nH2O (SU-101) 的灵感来自酚酸铋金属药物,可以在环境水条件下完全由无害或可食用试剂合成,从而实现简单的放大。试剂级和经济实惠的膳食补充剂级鞣花酸分别源自树皮和石榴壳。生物相容性和胶体稳定性通过体外测定得到证实。该材料在仿生 MOF 中表现出卓越的化学稳定性(pH = 2–14、水热条件、加热有机溶剂、生物介质、SO2 和 H2S),这归因于强螯合酚盐。记录的 H2S 吸收总量为 15.95 mmol g–1,代表 MOF 最高的 H2S 容量之一,其中多硫化物在材料的孔内形成。酚类植物化学物质作为 MOF 合成的连接剂在很大程度上仍未被探索,这为设计稳定、环保、可扩展和低成本的 MOF 开辟了新途径,用于多种应用,包括药物输送。
更新日期:2020-09-07
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