One-Step and One-Precursor Hydrothermal Synthesis of Carbon Dots with Superior Antibacterial Activity,ACS Applied Bio Materials

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One-Step and One-Precursor Hydrothermal Synthesis of Carbon Dots with Superior Antibacterial Activity
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-09-06 , DOI: 10.1021/acsabm.0c00923
Zhiguo Ye _{1,

2} , Guixin Li ₂ , Jing Lei ₁ , Mei Liu ₃ , Yan Jin ₁ , Baoxin Li ₁

Affiliation

Discovering efficient antibacterial materials is crucial in the area of increasing drug resistance. Herein, we synthesized carbon dots (C-dots) with superior antibacterial activity through a simple one-step hydrothermal method. In this method, p-phenylenediamine serves as not only the carbon source but also the origin for the functional group anchored on the obtained C-dots. The antibacterial activity of the obtained C-dots was tested against Staphylococcus aureus and Escherichia coli. The minimum bactericidal concentrations of the synthesized C-dots against S. aureus and E. coli were 2 and 30 μg/mL, respectively, which are lower than that of previously reported C-dots. The antibacterial mechanism was investigated, and the results indicated that a large number of −NH₃⁺ groups on the C-dots’ surface enhanced their antibacterial activity. Besides, the C-dots exhibited negligible cytotoxicity.

中文翻译：

一步一前体水热合成具有优异抗菌活性的碳点

发现有效的抗菌材料对于增加耐药性至关重要。在此，我们通过简单的一步水热法合成了具有优异抗菌活性的碳点（C-dots）。在该方法中，对苯二胺不仅作为碳源，而且作为锚定在所得碳点上的官能团的来源。对所获得的碳点的抗菌活性进行了针对金黄色葡萄球菌和大肠杆菌的测试。合成的碳点对金黄色葡萄球菌和大肠杆菌的最低杀菌浓度分别为 2 和 30 μg/mL，低于先前报道的碳点。对其抗菌机理进行了研究，结果表明碳点表面大量的-NH ₃^{+基团增强了其抗菌活性。}此外，碳点表现出可忽略不计的细胞毒性。

更新日期：2020-10-21

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