Purpose of review 

To illustrate successful reversal of hypertriglyceridemia using a very-low-carbohydrate ketogenic diet in conjunction with intermittent fasting in two patients.

Recent findings 

Hypertriglyceridemia remains an important component of residual risk for atherosclerotic cardiovascular disease. Current guidelines from the AHA/ACC recommend the initiation of a very-low-fat diet to treat persistently elevated triglycerides, whereas the National Lipid Association argues that a very-low-carbohydrate, high-fat diet is contraindicated in severe hypertriglyceridemia. In contrast, we report resolution of two cases of severe hypertriglyceridemia with implementation of very-low-carbohydrate ketogenic diets and intermittent fasting.

Summary 

Here, we describe two patients who have demonstrated substantial reductions in serum triglycerides, effectively reversing severe hypertriglyceridemia using unconventional dietary methods. Although anecdotal, these cases point to a critical lack of flexibility in current dietary guidelines that hinder their application in clinical practice.

中文翻译：

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间歇性禁食和低碳水化合物生酮饮食可逆转严重高甘油三酯血症：病例系列

审查目的 

为了说明在两名患者中使用极低碳水化合物的生酮饮食与间歇性禁食相结合成功逆转高甘油三酯血症的情况。

最近的发现 

高甘油三酯血症仍然是动脉粥样硬化性心血管疾病残留风险的重要组成部分。AHA / ACC的当前指南建议开始使用低脂饮食来治疗持续升高的甘油三酸酯，而美国国家脂质协会则认为，低碳水化合物，高脂饮食是严重高甘油三酯血症的禁忌症。相比之下，我们报告了使用低碳水化合物生酮饮食和间歇性禁食实施的两例严重高甘油三酯血症的解决方案。

概要 

在这里，我们描述了两名患者，他们表现出血清甘油三酸酯的大量减少，使用非常规饮食方法有效逆转了严重的高甘油三酸酯血症。尽管是偶然的，但这些病例表明当前饮食指南中严重缺乏灵活性，这阻碍了它们在临床实践中的应用。