Objective

To investigate the safety and efficacy of high-intensity focused ultrasound (HIFU) treatment for diffuse uterine leiomyomatosis (DUL).

Methods

Eight patients with DUL were admitted to the Department of Gynecology of Shanghai First Maternity and Infant Hospital and underwent HIFU treatment. MRI was performed before and one day after HIFU treatment for the evaluation of lesion ablation. The uterine size was measured at 3-8 months after HIFU ablation. The menstrual volume score and serum levels of hemoglobin and CA-125 were measured pre-HIFU ablation and 12-36 months post-HIFU ablation.

Results

After an average of 5.9 months of follow-up after HIFU treatment, an average uterine volume reduction of 67.6% was observed. Menstruation returned to normal in all patients, and their serum HGB and CA-125 levels also returned to normal after an average of 19.1 months of clinical follow-up. The quality of life of all patients improved significantly.

Conclusion

HIFU treatment is safe and effective in the treatment of patients with DUL.

中文翻译：

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高强度聚焦超声治疗弥漫性子宫平滑肌瘤的可行性研究。

目的

目的探讨高强度聚焦超声（HIFU）治疗弥漫性子宫平滑肌瘤病（DUL）的安全性和有效性。

方法

八例DUL患者被收治于上海第一妇婴医院妇科，并接受了HIFU治疗。HIFU治疗之前和之后进行MRI检查以评估病变消融情况。在HIFU消融后3-8个月测量子宫大小。在HIFU消融前和HIFU消融后12-36个月测量月经量分数和血红蛋白和CA-125的血清水平。

结果

HIFU治疗后平均5.9个月的随访后，平均子宫体积减少了67.6％。所有患者的月经恢复正常，平均临床随访19.1个月后，其血清HGB和CA-125水平也恢复正常。所有患者的生活质量显着改善。

结论

HIFU治疗对DUL患者安全有效。