Hepatocellular carcinoma (HCC) is the fifth most commonly diagnosed cancer worldwide and is associated with poor prognosis. The current study aimed to assess the therapeutic efficacy of resveratrol when administered alone and in combination with nicotinamide against alcohol‐aflatoxin B1‐induced HCC. Results reveal that during the development and progression of cancer, there was a decline in the level of antioxidant enzymes catalase, glutathione peroxidase, glutathione reductase (GR), antioxidant glutathione, and glutathione S‐transferase, which is an enzyme of detoxification pathways. Treatment of resveratrol restored the level of catalase and glutathione peroxidase toward normal in alcohol‐aflatoxin B1‐induced HCC; however, nicotinamide worked in concert with resveratrol only in upregulating the activity of glutathione reductase, glutathione level, and glutathione S‐transferase. SIRT1 agonist resveratrol was observed to modulate the activity of antioxidant enzymes by negatively regulating the expression of nuclear factor‐κB (NF‐κB) in alcohol‐aflatoxin B1‐induced HCC, thereby suggesting a cross‐talk between antioxidant enzymes SIRT1 and NF‐κB during the development and progression of HCC and its therapeutics by resveratrol and nicotinamide.

中文翻译：

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白藜芦醇和烟酰胺对酒精-黄曲霉毒素B1诱导的肝细胞癌中抗氧化酶，SIRT1和NF-κB的调节。

肝细胞癌（HCC）是全球第五大最常被诊断的癌症，与预后不良相关。当前的研究旨在评估白藜芦醇单独或与烟酰胺联合使用对酒精-黄曲霉毒素B1诱导的HCC的治疗效果。结果表明，在癌症的发生和发展过程中，抗氧化酶过氧化氢酶，谷胱甘肽过氧化物酶，谷胱甘肽还原酶（GR），抗氧化剂谷胱甘肽和谷胱甘肽S的水平下降。转移酶，是一种排毒途径的酶。白藜芦醇的治疗使酒精-黄曲霉毒素B1诱导的HCC中的过氧化氢酶和谷胱甘肽过氧化物酶水平恢复正常。但是，烟酰胺仅与白藜芦醇协同作用才能上调谷胱甘肽还原酶，谷胱甘肽水平和谷胱甘肽S-转移酶的活性。观察到SIRT1激动剂白藜芦醇通过负调节酒精-黄曲霉毒素B1诱导的HCC中核因子κB（NF-κB）的表达来调节抗氧化酶的活性，从而表明抗氧化酶SIRT1和NF-κB之间存在串扰。白藜芦醇和烟酰胺在肝癌及其治疗和发展过程中的作用。