Chromobox (CBX) family members are vital epigenetic regulators that repress the transcription of target genes through chromatin modification. Several studies have investigated the role of CBX family members in cancer. However, the function and prognostic value of diverse CBX family members in non‐small‐cell lung cancer remain largely unknown. In this study, we reveal that CBX family members are overexpressed in non‐small‐cell lung cancer tissue compared with normal lung tissue, with the exception of CBX6. Kaplan–Meier analysis demonstrated that high expressions of CBX1 and CBX3 are correlated with overall survival, disease‐specific survival, disease‐free interval, and progression‐free interval for patients with lung adenocarcinoma (LUAD). Furthermore, regression model analysis suggests that CBX3 may be suitable as an independent prediction factor for overall survival and progression‐free interval in patients with LUAD. In addition, CBX3 mRNA expression was found to be associated with tumor diameter and lymph node metastasis. Gene enrichment analysis suggests that CBX3 is involved in the cell cycle and P53 signaling pathways. Aberrant expression of CBX3 in LUAD is correlated with DNA copy number alteration. In summary, our data imply that CBX3 plays an important role in the promotion of LUAD and may thus have potential as a prognostic biomarker and molecular therapeutic target for the disease.

中文翻译：

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不同的 CBX 家族成员作为非小细胞肺癌的潜在预后生物标志物。

Chromobox (CBX) 家族成员是重要的表观遗传调节因子，通过染色质修饰抑制靶基因的转录。几项研究调查了 CBX 家族成员在癌症中的作用。然而，不同 CBX 家族成员在非小细胞肺癌中的功能和预后价值仍然很大程度上未知。在这项研究中，我们发现 CBX 家族成员与正常肺组织相比在非小细胞肺癌组织中过表达，但 CBX6 除外。Kaplan-Meier 分析表明，CBX1 和 CBX3 的高表达与肺腺癌 (LUAD) 患者的总生存期、疾病特异性生存期、无病期和无进展期相关。此外，回归模型分析表明，CBX3 可能适合作为 LUAD 患者总生存期和无进展间隔的独立预测因素。此外，发现CBX3 mRNA表达与肿瘤直径和淋巴结转移有关。基因富集分析表明 CBX3 参与细胞周期和 P53 信号通路。LUAD 中 CBX3 的异常表达与 DNA 拷贝数改变相关。总之，我们的数据表明 CBX3 在促进 LUAD 中发挥重要作用，因此可能具有作为该疾病的预后生物标志物和分子治疗靶点的潜力。基因富集分析表明 CBX3 参与细胞周期和 P53 信号通路。LUAD 中 CBX3 的异常表达与 DNA 拷贝数改变相关。总之，我们的数据表明 CBX3 在促进 LUAD 中发挥重要作用，因此可能具有作为该疾病的预后生物标志物和分子治疗靶点的潜力。基因富集分析表明 CBX3 参与细胞周期和 P53 信号通路。LUAD 中 CBX3 的异常表达与 DNA 拷贝数改变相关。总之，我们的数据表明 CBX3 在促进 LUAD 中发挥重要作用，因此可能具有作为该疾病的预后生物标志物和分子治疗靶点的潜力。