Osteosarcoma (OSA) arising from the digits, metatarsal and metacarpal bones is rare and may carry a better prognosis compared with other locations. The aim of this study was to retrospectively evaluate the biological behaviour, the progression free interval (PFI), the survival time (ST) and evaluate the effect of adjuvant chemotherapy for OSA affecting these bones. Medical records from two academic institutions were reviewed and 15 cases were included. Descriptive statistics were used for signalment and history. For estimation of median PFI and median ST, the Kaplan-Meier method was utilized. The prognostic effect of chemotherapy, lymphocyte and monocyte count was investigated. Log-rank analysis was used to compare PFI and ST between groups. The overall median PFI and median ST were 377 and 687 days, respectively. No significant differences were noted for any of the variables evaluated. In this study, dogs affected by OSA of digits, metacarpal and metatarsal bones appear to have a longer ST compared with dogs with OSA of other appendicular locations. A study with a larger number of patients is needed to confirm these results and investigate the potential benefit of adjuvant chemotherapy.

中文翻译：

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犬指、掌、跖骨原发性骨肉瘤的生物学行为

由手指、跖骨和掌骨引起的骨肉瘤 (OSA) 很少见，与其他部位相比，预后可能更好。本研究的目的是回顾性评估生物学行为、无进展间期 (PFI)、生存时间 (ST) 并评估辅助化疗对影响这些骨骼的 OSA 的效果。审查了两个学术机构的医疗记录，包括 15 例病例。描述性统计用于信号和历史。对于中值 PFI 和中值 ST 的估计，使用了 Kaplan-Meier 方法。研究了化疗、淋巴细胞和单核细胞计数对预后的影响。对数秩分析用于比较组间的 PFI 和 ST。总体中位 PFI 和中位 ST 分别为 377 天和 687 天。对于所评估的任何变量，均未发现显着差异。在这项研究中，受手指、掌骨和跖骨 OSA 影响的狗与患有其他附肢部位 OSA 的狗相比，似乎有更长的 ST。需要对更多患者进行研究来证实这些结果并调查辅助化疗的潜在益处。