Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
The complex life of rhomboid pseudoproteases.
The FEBS Journal ( IF 5.5 ) Pub Date : 2020-09-07 , DOI: 10.1111/febs.15548 Colin Adrain 1, 2 , Miguel Cavadas 1
The FEBS Journal ( IF 5.5 ) Pub Date : 2020-09-07 , DOI: 10.1111/febs.15548 Colin Adrain 1, 2 , Miguel Cavadas 1
Affiliation
|
Rhomboid pseudoproteases are catalytically inactive members of the rhomboid superfamily. The founding members, rhomboids, were first identified in Drosophila as serine intramembrane proteases that cleave transmembrane proteins, enabling signaling. This led to the discovery of the wider rhomboid superfamily, a clan that in metazoans is dominated by pseudoproteases. These so‐called rhomboid pseudoproteases inherited from their catalytically active ancestors a conserved rhomboid‐like domain and a propensity to regulate signaling. Lacking catalytic activity, they developed new ‘pseudoenzyme’ functions that include regulating the trafficking, turnover, and activity of their client proteins. Rhomboid pseudoproteases have preeminent roles in orchestrating immune cell activation, antiviral responses, and cytokine release in response to microbial infection, or in chronic diseases, and have also been implicated in growth factor signaling, cancer, and, more recently, metabolism. Here, we discuss the mechanism(s) of action of rhomboid pseudoproteases, contrasted with rhomboid proteases. We also highlight the roles of rhomboid pseudoproteases in mammalian physiology, which, quite paradoxically among pseudoenzymes, is understood much better than active rhomboids.
中文翻译：
菱形假蛋白酶的复杂寿命。
菱形假蛋白酶是菱形超家族的催化失活成员。最初的成员，菱形，最早是在果蝇中发现的作为丝氨酸膜内蛋白酶，可裂解跨膜蛋白，从而实现信号传导。这导致发现了更大的菱形超家族，这个家族在后生动物中主要由假蛋白酶组成。这些所谓的菱形假蛋白酶从其催化活性祖先继承来，具有保守的菱形样结构域和调节信号传导的倾向。由于缺乏催化活性，他们开发了新的“伪酶”功能，包括调节其客体蛋白的运输，周转和活性。菱形假蛋白酶在协调免疫细胞活化，抗病毒反应和响应微生物感染或慢性疾病的细胞因子释放方面起着重要作用，并且还与生长因子信号传导，癌症以及最近的新陈代谢有关。这里，我们讨论了菱形假蛋白酶的作用机理，与菱形蛋白酶相反。我们还强调了菱形假蛋白酶在哺乳动物生理学中的作用，在伪酶中，这很矛盾，与活性菱形相比，其理解要好得多。
更新日期：2020-10-07
中文翻译：
菱形假蛋白酶的复杂寿命。
菱形假蛋白酶是菱形超家族的催化失活成员。最初的成员，菱形，最早是在果蝇中发现的作为丝氨酸膜内蛋白酶，可裂解跨膜蛋白，从而实现信号传导。这导致发现了更大的菱形超家族，这个家族在后生动物中主要由假蛋白酶组成。这些所谓的菱形假蛋白酶从其催化活性祖先继承来，具有保守的菱形样结构域和调节信号传导的倾向。由于缺乏催化活性，他们开发了新的“伪酶”功能，包括调节其客体蛋白的运输，周转和活性。菱形假蛋白酶在协调免疫细胞活化，抗病毒反应和响应微生物感染或慢性疾病的细胞因子释放方面起着重要作用，并且还与生长因子信号传导，癌症以及最近的新陈代谢有关。这里，我们讨论了菱形假蛋白酶的作用机理，与菱形蛋白酶相反。我们还强调了菱形假蛋白酶在哺乳动物生理学中的作用，在伪酶中，这很矛盾，与活性菱形相比，其理解要好得多。
京公网安备 11010802027423号