In this article, the study on the swelling and thermal behaviors of a new series of bile acid‐based polymeric hydrogels is reported. For this purpose, in the first step, the reduction of carboxyl acid groups of some common bile acids including cholic acid (CA), chenodeoxy cholic acid (CDCA), and lithocholic acid (LCA) to the corresponding alcohols by lithium aluminum hydride (LiAlH₄) in THF solution is performed. Then, hydroxyl functionalities of the obtained products are reacted with the acryloyl chloride in the presence of triethylamine (TEA). Finally, the cross‐linking reactions between acryloyl functionalized bile acids and methoxy poly(ethylene glycol) monomethacrylate (MPEGMA) are conducted by free‐radical photo‐polymerization technique at λ = 350 nm in the presence of 2,2‐Dimethoxy‐2‐phenylacetophenone (DMPA) as an initiator to achieve the desired bile acid‐based polymeric hydrogels. The resulting hydrogels and their intermediates are characterized by Fourier transform infrared (FT‐IR) and Proton nuclear magnetic resonance (¹H‐NMR) spectroscopies. The swelling and thermal behavior of the obtained hydrogels indicates that the hydrogel starting from cholic acid is more swellable and has enhanced thermostability compared to others. Thus, the results of this study offer beneficial insights to researchers working in particularly bio‐medical industry.

中文翻译：

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自由基光聚合合成胆汁酸衍生的新型生物基水凝胶

本文报道了一系列新的基于胆汁酸的聚合物水凝胶的溶胀和热行为研究。为此，在第一步中，将一些常见的胆汁酸（包括胆酸（CA），鹅去氧胆酸（CDCA）和石胆酸（LCA））的羧基还原为氢化铝锂（LiAlH ₄）在THF溶液中进行。然后，将获得的产物的羟基官能度在三乙胺（TEA）的存在下与丙烯酰氯反应。最后，在2,2-二甲氧基-2-基存在下，通过自由基光聚合技术在λ= 350 nm下进行丙烯酰基官能化胆汁酸与甲氧基聚（乙二醇）单甲基丙烯酸酯（MPEGMA）之间的交联反应。苯基苯乙酮（DMPA）作为引发剂，以实现所需的基于胆汁酸的聚合物水凝胶。所得水凝胶及其中间体的特征在于傅立叶变换红外（FT-IR）和质子核磁共振（¹H-NMR）光谱学。所获得的水凝胶的溶胀和热行为表明，从胆酸开始的水凝胶与其他相比更溶胀并且具有增强的热稳定性。因此，这项研究的结果为从事特殊生物医学行业的研究人员提供了有益的见解。