The roles of carbonic anhydrases IX and XII in cancer cell adhesion, migration, invasion and metastasis,Biology of the Cell

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The roles of carbonic anhydrases IX and XII in cancer cell adhesion, migration, invasion and metastasis
Biology of the Cell ( IF 2.4 ) Pub Date : 2020-09-21 , DOI: 10.1111/boc.201900099
Simonas Daunys ₁ , Vilma Petrikaitė _{1,

2}

Affiliation

The main function of carbonic anhydrases (CAs) in cancer cells is the pH regulation through a conversion of H2O and CO2 to H+ and HCO3−. However, the data of in vitro and in vivo studies have demonstrated that transmembrane isoforms of CA IX and CA XII are involved in various steps of cancer cell migration, invasion and metastasis. According to literature, inhibition of these CAs can affect the expression of multiple proteins. Some scientific groups have reported the possible interactions between CA IX and E‐cadherin–catenin system, CA IX and integrins, CA IX, CA XII and ion transporters, which all are highly involved in cell‐to‐cell adhesion, the formation of membrane protrusions and focal adhesions. Nevertheless, CA IX and CA XII have a high impact on tumour growth and metastases formation. The data discussed in this review are quite recent. It highly support the role of CA IX and CA XII in various cancer metastasis processes through their interactions to other invasion proteins. Nevertheless, all findings show the great potential of these CAs in the context of research and application in clinical use.

中文翻译：

碳酸酐酶IX和XII在癌细胞粘附、迁移、侵袭和转移中的作用

碳酸酐酶 (CA) 在癌细胞中的主要功能是通过将 H2O 和 CO2 转化为 H+ 和 HCO3− 来调节 pH 值。然而，体内外研究数据表明，CA IX和CA XII的跨膜亚型参与了癌细胞迁移、侵袭和转移的各个步骤。根据文献，对这些 CA 的抑制会影响多种蛋白质的表达。一些科学小组报告了 CA IX 和 E-钙粘蛋白-连环蛋白系统、CA IX 和整合素、CA IX、CA XII 和离子转运蛋白之间可能的相互作用，它们都高度参与细胞间粘附、膜的形成突起和粘连。尽管如此，CA IX 和 CA XII 对肿瘤生长和转移形成有很大影响。本综述中讨论的数据是最近的。它通过与其他侵袭蛋白的相互作用高度支持 CA IX 和 CA XII 在各种癌症转移过程中的作用。尽管如此，所有研究结果都显示了这些 CA 在临床研究和应用中的巨大潜力。

更新日期：2020-09-21

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