Antibody‐mediated autoimmune diseases, such as autoimmune thyroid diseases (ATD), systemic lupus erythematosus (SLE), and antiphospholipid syndrome (APS), often are associated with recurrent fetal loss. One of the ATD is Hashimoto's thyroiditis which recently showed association with complications of pregnancy with increased levels of circulating autoantibodies reactive with epitopes on thyroid tissue such as thyroid peroxidase (anti‐TPO). In retrospective study of sera analyses in patients with Hashimoto's thyroiditis, all patients had mainly elevated circulating anti‐TPO autoantibodies.

中文翻译：

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循环桥本甲状腺炎衍生的 TPO 阳性 IgG 对幼稚小鼠胎儿丢失的致病作用

抗体介导的自身免疫性疾病，如自身免疫性甲状腺疾病 (ATD)、系统性红斑狼疮 (SLE) 和抗磷脂综合征 (APS)，通常与反复流产有关。ATD 之一是桥本氏甲状腺炎，它最近显示出与妊娠并发症相关，循环自身抗体水平升高，与甲状腺组织上的表位反应，如甲状腺过氧化物酶（抗 TPO）。在桥本甲状腺炎患者血清分析的回顾性研究中，所有患者的循环抗 TPO 自身抗体主要升高。