Microfluidic Biomaterials,Advanced Healthcare Materials

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Microfluidic Biomaterials
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-09-06 , DOI: 10.1002/adhm.202001028
Joe Tien _{1,

2} , Yoseph W Dance ₁

Affiliation

Since their initial description in 2005, biomaterials that are patterned to contain microfluidic networks (“microfluidic biomaterials”) have emerged as promising scaffolds for a variety of tissue engineering and related applications. This class of materials is characterized by the ability to be readily perfused. Transport and exchange of solutes within microfluidic biomaterials is governed by convection within channels and diffusion between channels and the biomaterial bulk. Numerous strategies have been developed for creating microfluidic biomaterials, including micromolding, photopatterning, and 3D printing. In turn, these materials have been used in many applications that benefit from the ability to perfuse a scaffold, including the engineering of blood and lymphatic microvessels, epithelial tubes, and cell‐laden tissues. This article reviews the current state of the field and suggests new areas of exploration for this unique class of materials.

中文翻译：

微流控生物材料

自 2005 年首次描述以来，包含微流体网络的生物材料（“微流体生物材料”）已成为各种组织工程和相关应用的有前途的支架。这类材料的特点是易于灌注。微流体生物材料内溶质的运输和交换受通道内的对流以及通道与生物材料本体之间的扩散控制。人们已经开发出多种策略来创建微流控生物材料，包括微成型、光图案化和 3D 打印。反过来，这些材料已被用于许多受益于支架灌注能力的应用中，包括血液和淋巴微血管、上皮管和充满细胞的组织的工程。本文回顾了该领域的现状，并提出了此类独特材料的新探索领域。

更新日期：2020-09-06

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