Responsive Polymer Brush Design and Emerging Applications for Nanotheranostics,Advanced Healthcare Materials

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Responsive Polymer Brush Design and Emerging Applications for Nanotheranostics
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-09-06 , DOI: 10.1002/adhm.202000953
Danyang Li _{1,

2,

3} , Lizhou Xu ₄ , Jing Wang ₅ , Julien E Gautrot _{2,

3}

Affiliation

Responsive polymer brushes are a category of polymer brushes that are capable of conformational and chemical changes in response to external stimuli. They offer unique opportunities for the control of bio−nano interactions due to the precise control of chemical and structural parameters such as the brush thickness, density, chemistry, and architecture. The design of responsive brushes at the surface of nanomaterials for theranostic applications has developed rapidly. These coatings can be generated from a very broad range of nanomaterials, without compromising their physical, photophysical, and imaging properties. Although the use of responsive brushes for nanotheranostic remains in its early stages, in this review, the aim is to present how the systems developed to date can be combined to control sensing, imaging, and controlled delivery of therapeutics. The recent developments for such design and associated methods for the synthesis of responsive brushes are discussed. The responsive behaviors of homo polymer brushes and brushes with more complex architectures are briefly reviewed, before the applications of responsive brushes as smart delivery systems are discussed. Finally, the recent work is summarized on the use of responsive polymer brushes as novel biosensors and diagnostic tools for the detection of analytes and biomarkers.

中文翻译：

响应性聚合物刷的设计和纳米化学的新兴应用

响应式聚合物刷是一类聚合物刷，能够响应外部刺激而发生构象变化和化学变化。由于对化学和结构参数（如刷子的厚度，密度，化学性质和结构）的精确控制，它们为控制生物纳米相互作用提供了独特的机会。用于纳米材料的响应材料刷在纳米材料表面的设计已得到快速发展。这些涂层可以由多种纳米材料制成，而不会影响其物理，光物理和成像性能。尽管使用响应式刷子进行纳米治疗仍处于早期阶段，但在本综述中，其目的是介绍如何将迄今为止开发的系统组合在一起，以控制传感，成像，并控制治疗药物的投放。讨论了这种设计和相关方法的最新发展，以合成响应画笔。在讨论响应式刷子作为智能输送系统的应用之前，简要回顾了均聚物刷和具有更复杂结构的刷子的响应行为。最后，对使用响应式聚合物刷作为新型生物传感器和用于检测分析物和生物标记物的诊断工具的最新工作进行了总结。

更新日期：2020-09-06

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