Purpose

Fractures are known to shorten life expectancy and worsen the quality of life. The risk of fractures after radiation therapy in cervical cancer patients is known to be multifactorial. In this study, we examined risk factors for fractures in cervical cancer patients, especially by evaluating bone densities and DVH parameters for fractured bones.

Materials and Methods

For 42 patients, clinical characteristics, pretreatment CT bone densities, and radiation dose were compared between patients with and without fractures.

Results

Posttreatment fractures occurred in 25 bones among ten patients. Pretreatment CT bone densities were significantly lower in patients with fractures (P < 0.05–0.01 across sites, except for the ilium and the ischium). Although DVH parameters were also significantly associated with fractures in univariate analysis, only CT densities were significantly associated with fractures in multivariate analysis.

Conclusion

Pretreatment CT densities of spinal and pelvic bones, which may reflect osteoporosis, have a significant impact on the risk for posttreatment fractures.

中文翻译：

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宫颈癌根治性放疗后骨折的预测因素。

目的

众所周知，骨折会缩短预期寿命并降低生活质量。众所周知，宫颈癌患者放射治疗后骨折的风险是多因素的。在这项研究中，我们检查了宫颈癌患者骨折的危险因素，特别是通过评估骨折的骨密度和 DVH 参数。

材料和方法

对于 42 名患者，比较有无骨折患者的临床特征、治疗前 CT 骨密度和辐射剂量。

结果

十名患者中有 25 根骨头发生了治疗后骨折。骨折患者的治疗前 CT 骨密度显着降低（各部位P  < 0.05–0.01，髂骨和坐骨除外）。尽管在单变量分析中 DVH 参数也与骨折显着相关，但在多变量分析中只有 CT 密度与骨折显着相关。

结论

治疗前脊柱和骨盆骨的 CT 密度可以反映骨质疏松症，对治疗后骨折的风险有显着影响。