Rice blast, caused by the fungus Magnaporthe oryzae, is a highly damaging disease. Introducing genes, which confer a broad spectrum resistance to the disease, such as Pib, makes an important contribution to protecting rice production. However, little is known regarding the mechanistic basis of the products of such genes. In this study, transcriptome of the cultivar Lijiangxintuanheigu (LTH) and its monogenic IRBLb-B which harbors Pib treated with M. oryzae were compared. Among the many genes responding transcriptionally to infection were some encoding products involved in the metabolism of ROS (reactive oxygen species), in jasmonate (JA) metabolism, and WRKY transcription factors, receptor kinases, and resistance response signal modulation. The down-regulation of genes encoding peroxiredoxin and glutathione S transferases implied that the redox homeostasis is essential for the expression of Pib-mediated resistance. The up-regulation of seven disease resistance-related genes, including three encoding a NBS-LRR protein, indicated that disease resistance-related genes are likely tend to support the expression of Pib resistance. These data revealed that potential candidate genes and transcriptional reprogramming were involved in Pib-mediated resistance mechanisms.

由稻瘟病菌引起的稻瘟病是一种高度破坏性的疾病。引入对这种疾病具有广谱抗性的基因，例如Pib，对保护水稻生产做出了重要贡献。然而，关于此类基因产物的机制基础知之甚少。在这项研究中，将栽培品种丽江新（LTH）及其单基因IRBLb-B其中怀有的转录组的Pib与处理过的稻瘟病菌进行比较。在对感染做出转录反应的许多基因中，有一些编码产物参与了ROS（活性氧）的代谢，茉莉酸（JA）的代谢以及WRKY转录因子，受体激酶和抗性应答信号的调控。编码过氧化物酶和谷胱甘肽S转移酶的基因的下调暗示氧化还原稳态对于表达Pib介导的抗性是必不可少的。七个抗病相关基因的上调，包括三个编码NBS-LRR蛋白的基因，表明抗病相关基因可能倾向于支持Pib抗性的表达。这些数据表明，Pib涉及潜在的候选基因和转录重编程。介导的抵抗机制。