Abstract –

The role of proteasome proteins and proteins of the ERAD system in the cytotoxicity of type II ribosome-inactivating proteins ricin and viscumin was investigated. For this, the cell line of colorectal adenocarcinoma HT29, as well as the HT29-sh002 line obtained on its basis, were used. On the basis on the proteome analysis of these lines and the estimation of the proportion of inactivated ribosomes, it was shown that the contribution of the proteasome to the degradation of the catalytic subunits of toxins is different. The role of the Cdc37 co-chaperone in maintaining the stability of A subunit of viscumin in the cytoplasm is shown.

中文翻译：

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PSMD11和其他蛋白酶体蛋白的表达水平与蓖麻毒素和粘蛋白的活性之间的关系。

摘要–

研究了蛋白酶体蛋白和ERAD系统蛋白在II型核糖体失活蛋白蓖麻毒素和粘蛋白中的细胞毒性中的作用。为此，使用了大肠腺癌HT29的细胞系以及以其为基础的HT29-sh002系。基于这些系的蛋白质组分析和灭活核糖体比例的估计，表明蛋白酶体对毒素催化亚基降解的贡献是不同的。显示了Cdc37伴侣蛋白在维持细胞质中黏蛋白A亚基稳定性方面的作用。