Abstract

This work is aimed at studying the mechanisms of reciprocal humoral regulation of noradrenaline-producing organs in rats in the perinatal period of development. The activity of noradrenaline synthesis enzymes tyrosine hydroxylase and dopamine-beta-hydroxylase was measured in the brain and adrenal glands 48 and 72 h after the injection of immunotoxin (anti-dopamine-beta-hydroxylase-saporin) into the rat brain ventricles. It was shown that, 48 h after the immunotoxin injection into the brain, the activity of tyrosine hydroxylase in the brain decreased; however, 72 h after the injection it reached the control levels. This fact indicates that noradrenaline synthesis in the survived neurons increases. In the adrenal glands, 72 h after the immunotoxin injection into the brain, the activity of dopamine-beta-hydroxylase increased. This points to a compensatory increase in the rate of noradrenaline synthesis in the adrenal glands when the synthesis of noradrenaline in the brain is inhibited.

中文翻译：

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脑在新生大鼠外周器官-去甲肾上腺素来源的调节中的作用：去甲肾上腺素合成酶活性。

摘要

这项工作旨在研究围产期大鼠去甲肾上腺素产生器官的相互体液调节机制。在向大鼠脑室注射免疫毒素（抗多巴胺-β-羟化酶-saporin）后48和72小时，在大脑和肾上腺中测量了去甲肾上腺素合成酶酪氨酸羟化酶和多巴胺-β-羟化酶的活性。结果表明，免疫毒素注射入脑后48 h，脑中酪氨酸羟化酶的活性下降。但是，注射后72小时达到了控制水平。这个事实表明存活的神经元中去甲肾上腺素的合成增加。在肾上腺，免疫毒素注射入脑后72小时，多巴胺-β-羟化酶的活性增加。