Chitosan-based emulsions functionalized with cabreuva essential oil (Myrocarpus fastigiatus) assembled with poly(vinyl alcohol) (PVA) were tailor-made to obtain a smooth, flexible and thin wound dressings capable for acting as a delivery vehicle. The cabreuva essential oil is composed mainly of trans-nerolidol, a natural compound with antimicrobial capacity that acts as a skin penetration enhancer. During the application of the dressing on skin explants, the penetration profile of cabreuva was analyzed through ex-vivo diffusion assays. Furthermore, the in-vivo essential oil delivery was followed by means of ATR-FTIR.

The addition of chitosan-based emulsions produced modifications in the properties of the composite dressings associated with the water affinity and gas permeability as well as in the mechanical behavior. The dressing functionalized with cabreuva essential oil combined with chitosan proved its effectiveness against microorganisms such as S. aureus and S. epidermidis, capacity to produce cell regeneration after 24 h of contact time, and no cytotoxicity in HaCaT cells. The material developed could be used in superficial burns or minor wounds such as dressings due to its demonstrated functionality as controlled release devices of the cabreuva essential oil.

量身定制的是用复合聚乙烯醇（PVA ）组装的Cabreuva精油（Myrocarpus fastigiatus）功能化的壳聚糖乳液，可获得光滑，柔软且薄的伤口敷料，可以用作输送工具。Cabreuva精油主要由反式橙花醇构成，这是一种具有抗菌能力的天然化合物，可作为皮肤渗透促进剂。在将该敷料应用于皮肤外植体的过程中，通过离体扩散测定法分析了cabreuva的渗透概况。此外，通过ATR-FTIR进行体内精油递送。

基于壳聚糖的乳液的添加改变了与水亲和力和透气性相关的复合敷料的性能以及机械性能。用cabreuva精油与壳聚糖结合功能化的敷料证明了其对微生物如金黄色葡萄球菌和表皮葡萄球菌的有效性，在接触24小时后能够产生细胞再生，并且在HaCaT细胞中无细胞毒性。所开发的材料由于具有证明作为Cabreuva精油的控释装置的功能，因此可用于浅表烧伤或轻微伤口（例如敷料）。