Sleep is essential for the survival of most living beings. Numerous researchers have identified a series of genes that are thought to regulate sleep-state or the deprived state. As sleep has significant effect on physiology, we believe that lack of sleep or particularly REM sleep for a prolonged period would have a profound impact on various body tissues. Therefore, using micro-array method, we sought to determine which genes and processes are affected in the brain and liver of rats following 9 days of REM sleep deprivation. Our findings showed that REM sleep deprivation affected a total of 652 genes in the brain and 426 genes in the liver. Only 23 genes were affected commonly, 10 oppositely and 13 similarly across brain and liver tissue. Our results suggest that 9-day REM sleep deprivation diferentially affects genes and processes in the brain and liver of rats.

中文翻译：

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快速动眼睡眠剥夺后Wistar大鼠脑和肝组织中的差异基因表达

睡眠对于大多数生物的生存至关重要。许多研究人员已经鉴定出一系列基因，这些基因可以调节睡眠状态或剥夺状态。由于睡眠对生理机能有重要影响，因此我们认为，长时间缺乏睡眠（尤其是REM睡眠）将对各种身体组织产生深远影响。因此，使用微阵列方法，我们试图确定在REM睡眠剥夺9天后大鼠脑和肝中哪些基因和过程受到影响。我们的研究结果表明，REM睡眠剥夺影响了大脑中的652个基因和肝脏中的426个基因。通常只有23个基因受到影响，在脑和肝组织中分别受到10个相反的影响和13个类似的影响。