Loneliness, the subjective experience of social isolation, represents one of the largest risk factors for physical illness and early death in humans. However, the mechanisms by which loneliness leads to adverse health outcomes are not well understood.

中文翻译：

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慢性和状态孤独对女性心率变异性的影响。

孤独是社会孤立的主观体验，是人类身体疾病和早逝的最大风险因素之一。然而，孤独导致不良健康结果的机制尚不清楚。