The advanced glycosylation end product receptor (RAGE) acts as a recognition receptor and interacts with different types of ligands that form and accumulate in the tissues and circulation, such as diabetes, inflammation, insulin resistance, and obesity. In these environments, RAGE is expressed on the surface of various cells associated with tissue disturbance. This review mainly summarizes the characteristics of RAGE-related signalling, with a particular emphasis on the role of RAGE in the development of obesity. We also briefly describe the phenotypes and characteristics of macrophages and focus on the role of adipose tissue macrophages (ATMs) and the regulatory mechanisms in obesity, diabetes, and other related metabolic diseases. Besides, we will also elaborate on the prospect of new strategies for treating diabetes and obesity-related metabolic diseases by inhibiting RAGE signalling and regulating ATMs recruitment and polarization.

先进的糖基化终产物受体（RAGE）充当识别受体，并与在组织和循环中形成和积累的不同类型的配体相互作用，例如糖尿病，炎症，胰岛素抵抗和肥胖症。在这些环境中，RAGE在与组织紊乱相关的各种细胞的表面表达。这篇综述主要总结了RAGE相关信号的特征，特别强调了RAGE在肥胖症发展中的作用。我们还简要描述了巨噬细胞的表型和特征，并着重于脂肪组织巨噬细胞（ATM）的作用以及肥胖，糖尿病和其他相关代谢性疾病的调控机制。除了，