Injectable dextran‐fluorenylmethoxycarbonyl phenylalanine composite hydrogels with improved mechanical properties,Polymer International

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Injectable dextran‐fluorenylmethoxycarbonyl phenylalanine composite hydrogels with improved mechanical properties
Polymer International ( IF 2.9 ) Pub Date : 2020-09-05 , DOI: 10.1002/pi.6118
Jancy N Abraham ₁ , Seena Joseph ₁ , Rishabh Trivedi ₁ , Mrunal Karle ₁

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Low molecular weight hydrogels are recently gaining importance owing to their applications in material sciences and biology. A new class of composite hydrogel was developed using polysaccharides such as dextran and fluorenylmethoxycarbonyl phenylalanine (FmocF) in a phosphate buffer. The molecular weight and concentration of the dextran were varied to obtain rigid but injectable hydrogels without using other crosslinking agents. From the different molecular weights of dextran studied (5k, 40k and 70k), a combination of FmocF (0.6% w/v) and dextran 40k (0.012% w/v) composite gels yielded a maximum value of storage modulus of approximately 1500 Pa, which is 3.5 times higher than the storage modulus of pure FmocF gels. Scanning electron microscopy of FmocF/dextran composite gels revealed highly tangled fibrous structures with dense branches and lower fiber diameter compared to pure FmocF gels. The high‐intensity hydrogen‐bonded N–H peak in the infrared spectra showed enhanced hydrogen bonding in FmocF/dextran composite gels compared to pure FmocF gels. The dextran acts as an impurity in the process of fibrillation, leading to a crystallographic mismatch, and densely packed thin fibers are formed. These gels exhibited gel to sol and sol to gel conversion with temperature or external stress and showed injectable behavior. © 2020 Society of Industrial Chemistry

中文翻译：

具有改善的机械性能的可注射右旋糖酐-芴基甲氧基羰基苯丙氨酸复合水凝胶

低分子量水凝胶由于其在材料科学和生物学中的应用，最近变得越来越重要。在磷酸盐缓冲液中使用葡聚糖和芴基甲氧基羰基苯丙氨酸（FmocF）等多糖开发了一类新型复合水凝胶。改变葡聚糖的分子量和浓度以获得刚性但可注射的水凝胶，而无需使用其他交联剂。根据所研究的不同分子量的右旋糖酐（5k，40k和70k），FmocF（0.6％w / v）和右旋糖酐40k（0.012％w / v）复合凝胶的组合产生的最大储能模量约为1500 Pa ，是纯FmocF凝胶的储能模量的3.5倍。与纯FmocF凝胶相比，FmocF /葡聚糖复合凝胶的扫描电子显微镜显示高度缠结的纤维结构，具有致密的分支和较低的纤维直径。与纯FmocF凝胶相比，FmocF /葡聚糖复合凝胶的红外光谱中高强度氢键N–H峰显示出增强的氢键。右旋糖酐在原纤化过程中充当杂质，导致晶体学不匹配，并形成紧密堆积的细纤维。这些凝胶在温度或外部应力下表现出从凝胶到溶胶的转变以及从溶胶到凝胶的转变，并表现出可注射的行为。©2020工业化学学会右旋糖酐在原纤化过程中充当杂质，导致晶体学不匹配，并形成紧密堆积的细纤维。这些凝胶在温度或外部应力下表现出从凝胶到溶胶的转变以及从溶胶到凝胶的转变，并表现出可注射的行为。©2020工业化学学会右旋糖酐在原纤化过程中充当杂质，导致晶体学不匹配，并形成紧密堆积的细纤维。这些凝胶在温度或外部应力下表现出从凝胶到溶胶的转变以及从溶胶到凝胶的转变，并表现出可注射的行为。©2020工业化学学会

更新日期：2020-09-05

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