Calcium oxalate kidney stones, where is the organic matter?: A synchrotron based infrared microspectroscopy study.,Journal of Biophotonics

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Calcium oxalate kidney stones, where is the organic matter?: A synchrotron based infrared microspectroscopy study.
Journal of Biophotonics ( IF 2.0 ) Pub Date : 2020-09-06 , DOI: 10.1002/jbio.202000303
Iris H Valido ₁ , Montserrat Resina-Gallego ₁ , Ibraheem Yousef ₂ , Maria Pilar Luque-Gálvez ₃ , Manuel Valiente ₁ , Montserrat López-Mesas ₁

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Kidney stones are collections of microcrystals formed inside the kidneys, which affect 6% to 12% of the population worldwide, with an increasing recurrence (50%‐72%) after the first episode. The most abundant type is calcium oxalate (66%), described as monohydrated (COM) and dihydrated (COD). An issue in their chemistry is the transformation process of the metastable specie (COD) into the stable one, which is chemically, and in appearance, monohydrated. Since the origin of these species is different, it is important to differentiate between the transformation stage (and what stabilize COD) to understand the physiopathology and prevent the patients' recurrence. This work focuses on the organic matter distribution along these nephroliths by synchrotron radiation‐based infrared microspectroscopy. Differences in the asymmetric stretching of the aliphatic hydrocarbons suggest that lipids may participate in the stabilization of COD and as inhibitors of COM formation/development; however, the presence of proteins in the nucleus could indicate a promoting role.

中文翻译：

草酸钙肾结石，有机物在哪里？：基于同步加速器的红外显微研究。

肾结石是在肾脏内部形成的微晶的集合体，这些微晶会影响全世界6％至12％的人口，并且首发后复发率会增加（50％-72％）。最丰富的类型是草酸钙（66％），被描述为一水合（COM）和二水合（COD）。他们化学上的一个问题是亚稳态物种（COD）转变为稳定的物种的过程，该过程在化学上和外观上都是一水合的。由于这些物种的起源不同，因此重要的是要区分转化阶段（和稳定COD的阶段），以了解生理病理学并防止患者复发。这项工作的重点是通过基于同步加速器辐射的红外显微技术沿着这些肾石的有机质分布。脂族烃不对称拉伸的差异表明，脂质可能参与了COD的稳定作用，并成为COM形成/发展的抑制剂。然而，蛋白质在细胞核中的存在可能表明其具有促进作用。

更新日期：2020-09-06

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