Pixel-level angular quantification of capsular collagen in second harmonic generation microscopy images of encapsulated thyroid nodules.,Journal of Biophotonics

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Pixel-level angular quantification of capsular collagen in second harmonic generation microscopy images of encapsulated thyroid nodules.
Journal of Biophotonics ( IF 2.0 ) Pub Date : 2020-09-05 , DOI: 10.1002/jbio.202000262
Radu Hristu ₁ , Lucian G Eftimie _{1,

2,

3} , Bogdan Paun _{1,

4} , Stefan G Stanciu ₁ , George A Stanciu ₁

Affiliation

Polarization‐resolved second harmonic generation microscopy is used to provide pixel‐level angular distribution of collagen in thyroid nodule capsules. The pixel‐level angular distribution is combined with textural analysis to quantify the collagen distribution in follicular adenoma (benign) and papillary thyroid carcinoma (malignant). Three second order nonlinear susceptibility tensor elements ratios, the collagen angular distribution and two parameters accounting for the collagen angular dispersion in different sized areas are extracted and corresponding images are computed in a pixel‐by‐pixel fashion. Subsequently, we show that texture analysis can be performed on these images to detect significant differences between the considered benign and malignant nodule capsules.

中文翻译：

囊状甲状腺结节的二次谐波显微镜图像中囊状胶原蛋白的像素级角量化。

偏振分辨二次谐波显微镜用于提供甲状腺结节胶囊中胶原蛋白的像素级角分布。像素级角度分布与纹理分析相结合，以量化滤泡性腺瘤（良性）和甲状腺乳头状癌（恶性）中的胶原蛋白分布。提取三个二阶非线性磁化率张量元素比率，胶原蛋白角分布和两个参数，这些参数解释了不同大小区域中的胶原蛋白角散度，并以逐像素的方式计算了相应的图像。随后，我们表明可以对这些图像进行纹理分析，以检测所考虑的良性和恶性结节囊之间的显着差异。

更新日期：2020-09-05

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