With an increase in sedentary lifestyle and dietary over nutrition, obesity has become one of the major public health problems worldwide and is a prevalent predisposing risk factor to non‐alcoholic fatty liver disease (NAFLD), the most common chronic liver disease in Western developed countries. NAFLD represents a series of diseased states ranging from non‐alcoholic fatty liver (NAFL) to steatohepatitis (NASH), which can lead to fibrosis and eventually to cirrhosis and hepatocellular carcinoma. Currently, the only effective treatment to cure end‐stage liver disease is liver transplantation. Macrophages have been reported to play a crucial role in the progression of NAFLD, thereby are a potential target for therapy. In this review, we discuss the current knowledge on the role of macrophages and inflammatory signalling pathways associated with obesity and chronic liver inflammation, and their contribution to NAFLD development and progression.

中文翻译：

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肥胖相关非酒精性肝脂肪病（NAFLD）中的巨噬细胞和清道夫受体。


随着久坐生活方式和饮食营养过剩的增加，肥胖已成为全球主要公共卫生问题之一，也是西方发达国家最常见的慢性肝病非酒精性脂肪性肝病（NAFLD）的普遍诱发危险因素。 NAFLD代表一系列疾病状态，从非酒精性脂肪肝（NAFL）到脂肪性肝炎（NASH），可导致纤维化并最终导致肝硬化和肝细胞癌。目前，治愈终末期肝病唯一有效的治疗方法是肝移植。据报道，巨噬细胞在 NAFLD 的进展中发挥着至关重要的作用，因此是潜在的治疗靶点。在这篇综述中，我们讨论了目前关于巨噬细胞和炎症信号通路与肥胖和慢性肝脏炎症相关的作用的知识，以及它们对 NAFLD 发生和进展的贡献。