Stimulatory effects of Paederia foetida flower absolute on the skin wound and barrier repair activities of keratinocytes,Chemistry & Biodiversity

当前位置： X-MOL 学术 › Chem. Biodivers. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Stimulatory effects of Paederia foetida flower absolute on the skin wound and barrier repair activities of keratinocytes
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2020-10-01 , DOI: 10.1002/cbdv.202000506
Ha Bin Kim _{1,

2} , Kyung Jong Won ₃ , Do Yoon Kim ₁ , Hye Min Kang ₁ , Hwan Myung Lee ₁

Affiliation

Paederia foetida (PF) has antidiarrheal, antidiabetic, and anti‐inflammatory activities. However, its biological activities on skin remain unclear. In this study, we examined the effect of PF flower absolute (PFFA) on skin wound healing‐ and skin barrier‐linked responses in human epidermal keratinocytes (HaCaT cells). PFFA contained 23 components and increased the proliferation and sprout outgrowth of HaCaT cells and modestly increased migration. PFFA enhanced the phosphorylation levels of extracellular signal‐regulated kinase1/2, serine/threonine‐specific protein kinase (AKT), and p38 mitogen‐activated protein kinase (MAPK) in HaCaT cells, and upregulated type I and IV collagen synthesis and filaggrin (an epidermal barrier protein) expression in HaCaT cells. These findings suggest PFFA may promote skin wound repair by stimulating migratory and proliferative activities (probably through the AKT/MAPK pathway), collagen synthesis, and skin barrier repair by upregulating the expressions of filaggrin in epidermal keratinocytes. Therefore, PFFA may be useful for developing agents that enhance skin wound and barrier‐repair functions.

中文翻译：

Paederia foetida flower absolute 对皮肤创面及角质形成细胞屏障修复活性的刺激作用

Paederia foetida (PF) 具有止泻、抗糖尿病和抗炎活性。然而，其对皮肤的生物活性尚不清楚。在这项研究中，我们检查了 PF 花绝对 (PFFA) 对人表皮角质形成细胞 (HaCaT 细胞) 中皮肤伤口愈合和皮肤屏障相关反应的影响。PFFA 含有 23 种成分，可增加 HaCaT 细胞的增殖和发芽生长，并适度增加迁移。PFFA 增强了 HaCaT 细胞中细胞外信号调节激酶 1/2、丝氨酸/苏氨酸特异性蛋白激酶 (AKT) 和 p38 丝裂原活化蛋白激酶 (MAPK) 的磷酸化水平，并上调了 I 型和 IV 型胶原合成和聚丝蛋白。表皮屏障蛋白）在 HaCaT 细胞中的表达。这些发现表明 PFFA 可能通过刺激迁移和增殖活动（可能通过 AKT/MAPK 途径）、胶原合成和皮肤屏障修复，通过上调表皮角质形成细胞中丝聚蛋白的表达来促进皮肤伤口修复。因此，PFFA 可用于开发增强皮肤伤口和屏障修复功能的药物。

更新日期：2020-10-01

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11