Porcine circovirus type2 (PCV2) is a member of the circoviridae family. PCV2 was identified as the main pathogen of postweaning multisystemic wasting syndrome (PMWS) in weaned piglets and causes massive economic loss. Basigin, is a transmembrane glycoprotein belonging to the immunoglobulin superfamily; which is also a receptor for cyclophilins. CyP belongs to the immunophilin family that has peptidyl-prolyl cis-trans isomerase activity. Basigin-CyP interaction affects the replication stages of several viruses. In this study, we found that Basigin could elevate the replication of PCV2, and the Basigin only affected the replication stage rather than adsorption or endocytosis stages. In addition, the ligands of Basigin, CyPA and CyPB also elevated the replication of PCV2. Basigin-CyP interation was necessary for elevating PCV2 replication; At last, CyPs were proved to promote the replication of PCV2 by activating ERK signaling.

猪圆环病毒 2 型 (PCV2) 是圆环病毒科的成员。PCV2被确定为断奶仔猪断奶后多系统衰竭综合征（PMWS）的主要病原体，并造成巨大的经济损失。Basigin，是属于免疫球蛋白超家族的跨膜糖蛋白；这也是亲环蛋白的受体。CyP 属于具有肽基-脯氨酰顺反异构酶活性的亲免素家族。Basigin-CyP 相互作用影响几种病毒的复制阶段。在这项研究中，我们发现 Basigin 可以提高 PCV2 的复制，并且 Basigin 只影响复制阶段，而不是吸附或内吞阶段。此外，Basigin、CyPA 和 CyPB 的配体也提高了 PCV2 的复制。Basigin-CyP 相互作用对于提高 PCV2 复制是必要的；最后，