The integrity of the perirhinal cortex (PRh) is essential for object recognition memory (ORM) function, and damage to this brain area in animals and humans induces irreversible ORM deficits. Here, we show that activation of area V2, a brain area interconnected with brain circuits of ventral stream and medial temporal lobe that sustain ORM, by expression of regulator of G-protein signaling 14 of 414 amino acids (RGS14₄₁₄) restored ORM in memory-deficient PRh-lesioned rats and nonhuman primates. Furthermore, this treatment was sufficient for full recovery of ORM in rodent models of aging and Alzheimer’s disease, conditions thought to affect multiple brain areas. Thus, RGS14₄₁₄-mediated activation of area V2 has therapeutic relevance in the recovery of recognition memory, a type of memory that is primarily affected in patients or individuals with symptoms of memory dysfunction. These findings suggest that area V2 modulates the processing of memory-related information through activation of interconnected brain circuits formed by the participation of distinct brain areas.

周围神经皮层（PRh）的完整性对于对象识别记忆（ORM）功能至关重要，而对动物和人类大脑区域的损害会导致不可逆的ORM缺陷。在这里，我们显示区域V2的激活，即通过维持414个氨基酸（RGS14 ₄₁₄）的G蛋白信号传导14的G蛋白信号调节子的表达，与维持ORM的腹侧流和内侧颞叶的脑回路互连的脑区域PRh损伤的大鼠和非人类灵长类动物。此外，这种治疗足以在衰老和阿尔茨海默氏病的啮齿动物模型中完全恢复ORM，这些疾病被认为会影响多个大脑区域。因此，RGS14 ₄₁₄介导的区域V2的激活在识别记忆的恢复中具有治疗意义，识别记忆是一种主要在具有记忆功能障碍症状的患者或个人中受到影响的记忆类型。这些发现表明，区域V2通过激活由不同大脑区域参与而形成的互连大脑回路来调节与记忆有关的信息的处理。