In this work, the porous structures of cellulose aerogel monoliths and microparticles are analyzed and the potential of cellulose aerogel microparticles in drug delivery is assessed. Cellulose dissolved in ionic liquid and N,N-dimethylformamide mixed solvents are regenerated into gels using antisolvent ethanol. The gels are then supercritically dried in carbon dioxide to obtain aerogels. Gel monoliths are cast inside a mold, while the gel microparticles of mean diameter 23–54 μm are obtained by emulsifying cellulose solutions in a surfactant-stabilized oil-in-oil emulsion system followed by regeneration in ethanol. Cellulose crystallinity, porosity and pore architecture, bulk density, and specific surface area of aerogel monoliths and microparticles are determined. In conjunction, the effects of water ingress on changes of pore architectures are assessed. These aerogel specimens show porosity as high as 99%, significant mesopores, and high specific surface area of 358 ± 13 m²/g and 426 ± 12 m²/g respectively for monoliths and microparticles. The porous architecture of the microparticles is responsible for slower release of the drug than when directly loaded into aqueous medium.

在这项工作中，分析了纤维素气凝胶单块和微粒的多孔结构，并评估了纤维素气凝胶微粒在药物递送中的潜力。使用抗溶剂乙醇将溶解在离子液体和N，N-二甲基甲酰胺混合溶剂中的纤维素再生为凝胶。然后将凝胶在二氧化碳中超临界干燥以获得气凝胶。凝胶单块被浇铸在模具内部，而平均直径23–54μm的凝胶微粒是通过在表面活性剂稳定的油包油乳液系统中乳化纤维素溶液，然后在乙醇中再生而获得的。确定了纤维素的结晶度，孔隙率和孔隙结构，堆积密度以及气凝胶单块和微粒的比表面积。结合起来 评估了进水对孔隙结构变化的影响。这些气凝胶样品显示出高达99％的孔隙率，显着的中孔和358±13 m的高比表面积整料和微粒分别为² / g和426±12 m ² / g。与直接加载到水性介质中相比，微粒的多孔结构可导致药物释放缓慢。