Abstract Hemodialysis membranes have been widely used for the treatment of chronic kidney disease. However, as common hemodialysis membranes, polysulfone based membranes are suffering from complicated modification to improve hemocompatibility and safety issues of additive leaching-out. Facing these challenges, here hemodialysis membranes with excellent hemocompatibility and biocompatibility were fabricated by nonsolvent induced phase separation (NIPS) of a block copolymer, polysulfone-block-poly(ethylene glycol) (PSF-b-PEG), without using any additives. During NIPS, mesopores were formed throughout the membrane and the PEG chains were preferentially enriched on surfaces, thus improving the hydrophilicity. In-vitro compatibility and performance of the PSF-b-PEG membranes as well as protein adsorption, hemolysis, platelet adhesion, ultrafiltration coefficient, solute rejection and toxin clearance were studied. Due to the intrinsic existence of hydrophilic and biocompatible PEG on surface, the PSF-b-PEG membranes exhibited superior hemodialysis performances than traditional membranes, demonstrating their promise for hemodialysis.

中文翻译：

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由聚砜和聚乙二醇嵌段共聚物无添加剂制备血液透析膜

摘要 血液透析膜已广泛应用于慢性肾脏病的治疗。然而，作为常见的血液透析膜，聚砜膜面临着复杂的改性以提高血液相容性和添加剂浸出的安全问题。面对这些挑战，这里通过嵌段共聚物聚砜-嵌段-聚（乙二醇）（PSF-b-PEG）的非溶剂诱导相分离（NIPS）制造了具有优异血液相容性和生物相容性的血液透析膜，而不使用任何添加剂。在 NIPS 过程中，在整个膜上形成了中孔，PEG 链优先富集在表面上，从而提高了亲水性。PSF-b-PEG 膜的体外相容性和性能以及蛋白质吸附、溶血、血小板粘附、研究了超滤系数、溶质排斥和毒素清除。由于表面亲水性和生物相容性 PEG 的固有存在，PSF-b-PEG 膜表现出优于传统膜的血液透析性能，证明了它们在血液透析方面的前景。