The aims of this work were to evaluate the antibacterial and antiproliferative potential in vitro of the metal complex with 4-aminobenzoic acid (Ag-pABA) and a drug delivery system based on bacterial cellulose (BC-Ag-pABA). The Ag-pABA complex was characterized by elemental analysis, high resolution mass spectrometry and single-crystal X-ray diffraction techniques, which indicated a 1:2 metal/pABA composition plus a nitrate ion coordinated to silver by the oxygen atom, with the coordination formula [Ag (C₇H₇NO₂)₂(NO₃)]. The coordination of pABA to the silver ion occurred by the nitrogen atom. The in vitro antibacterial activity of the complex evaluated by minimum inhibitory concentration assays demonstrated the effective growth inhibitory activity against Gram-positive, Gram-negative biofilm producers and acid-alcohol resistant Bacillus. The antiproliferative activities against a panel of eight tumor cells demonstrated the activity of the complex with a significant selectivity index (SI). The DNA interaction capacity and the Ames Test indicated the absence of mutagenicity. The BC-Ag-pABA composite showed an effective capacity of sustained release of Ag-pABA. The observed results validate further studies on its mechanisms of action and the conditions that mediate the in vivo biological effects using animal models to confirm its safety and effectiveness for treatment of skin and soft tissues infected by bacterial pathogens, urinary tract infections and cancer.

这项工作的目的是评估具有 4-氨基苯甲酸 (Ag-pABA) 的金属络合物和基于细菌纤维素的药物递送系统 (BC-Ag- p ABA) 的体外抗菌和抗增殖潜力。Ag- p ABA 复合物通过元素分析、高分辨率质谱和单晶 X 射线衍射技术进行表征，表明 1:​​2 的金属/ p ABA 组成加上通过氧原子与银配位的硝酸根离子，与配位式[Ag (C ₇ H ₇ NO ₂ ) ₂ (NO ₃ )]。p的协调ABA对银离子的发生是由氮原子产生的。在体外复由最小抑制浓度测定法评价抗菌活性表现出对革兰氏阳性，革兰氏阴性生物膜生产者和有效的生长抑制活性酸-醇性芽孢杆菌。针对一组八个肿瘤细胞的抗增殖活性证明了复合物的活性，具有显着的选择性指数 (SI)。DNA 相互作用能力和 Ames 试验表明不存在致突变性。BC-Ag- p ABA 复合材料显示出有效的 Ag- p缓释能力ABA。观察到的结果验证了对其作用机制和使用动物模型介导体内生物学效应的条件的进一步研究，以确认其治疗被细菌病原体感染的皮肤和软组织、尿路感染和癌症的安全性和有效性。