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An experimental evaluation of a concept to improve conventional aortic prostheses
Journal of Biomechanics ( IF 2.4 ) Pub Date : 2020-09-05 , DOI: 10.1016/j.jbiomech.2020.110010
C. Legerer , M. Stevens , G.M. Vazquez , T. Müller , L. Ferrington

Conventionally used textile prosthesis for traditional open surgical repair (OSR) of aortic aneurysms have a lower compliance than the native aortic tissue. Graft placements lead to an acute drop in compliance which effects cardiovascular risk and the development of graft related complications. A custom-made spring casing was applied to a Dacron graft segment under physiological pressure conditions within a five-element biventricular mock circulation loop, to investigate experimentally a concept to improve the compliance of a conventional aortic prosthesis by changing the transverse graft cross-section. Two different prosthesis locations, proximal and distal of compliant silicone tubing were used to study uniaxial graft compression with an elastic device. To characterise the devices’ performance by means of pulse pressure (PP), diastolic pressure (Pdia) and pulse wave velocity (PWV), fluid pressures and flow were recorded.

In a proximal graft setting (ascending aorta repair) elastic uniaxial compression with a custom-made spring casing (2 cm width) could significantly reduce PP by 10–14% (p < .001) and slowed PWV from 6.7 to 5.2 m/s (22%, p = .002). Applied to a graft in a distal position, the spring casing demonstrated less impact on PP (2–10%), but significantly reduced PWV in this mock aorta segment from 13.7 to 5.5 m/s (60%, p = .004). In conclusion, a newly conceptualised spring casing applied to the external wall of synthetic aortic grafts can reduce PP and slow PWV. By restoring elastic aortic recoil in stiff textile aortic prostheses, the presented concept is a potential solution to improve long-term aortic prosthesis related complications.



中文翻译:

对改进传统主动脉假体的概念进行实验评估

传统上用于主动脉瘤的传统开放手术修复(OSR)的织物假体的柔顺性低于天然主动脉组织。移植物的放置会导致顺应性急剧下降,这会影响心血管疾病的风险以及与移植物相关的并发症的发展。在生理压力条件下,在五元双心室模拟循环回路中,在生理压力条件下,将定制的弹簧套管应用于Dacron移植物节段,以实验研究一种通过改变横向移植物横截面来改善常规主动脉假体顺应性的概念。顺应性硅胶管的近端和远端两个不同的假体位置用于研究使用弹性装置进行的单轴移植物压缩。为了通过脉冲压力(PP)表征设备的性能,直径)和脉搏波速度(PWV),流体压力和流量被记录下来。

在近端移植物设置(升主动脉修复)中,使用定制弹簧套管(2 cm宽度)进行弹性单轴压缩可将PP显着降低10–14%(p <.001),并将PWV从6.7降低至5.2 m / s (22%,p = .002)。弹簧套应用于远端位置时,弹簧套对PP的影响较小(2-10%),但该模拟主动脉节段的PWV从13.7降至5.5 m / s(60%,p = .004)。总之,将新概念化的弹簧套管应用于合成主动脉移植物的外壁可以减少PP和减慢PWV。通过恢复硬质织物主动脉假体中的弹性主动脉后坐力,提出的概念是改善长期主动脉假体相关并发症的潜在解决方案。

更新日期:2020-09-23
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